Join our generation.

Senior Scientist / Principal Scientist, Delivery

Cambridge, Massachusetts, United States

Generation Bio is a biotechnology company leading a new generation of gene therapy. With our proprietary re-dosable ceDNA technology, we are expanding the reach of gene therapy At Generation Bio, our goal is to bring the life-saving benefits of gene therapy to more people, living with a broader range of diseases, in more places around the world. Our vision is to make the ravages of genetic disease as imaginary to the next generation as polio feels to children today.

We are a thriving, collaborative, creative community of diverse talents, beliefs, and experiences relentlessly dedicated to our mission. Founded and launched by Atlas Venture. Headquartered in Cambridge, Massachusetts. Committed to a future where more people can live full lives.

Delve further. Please visit or follow @generationbio.


Generation Bio seeks an energetic and highly motivated scientist to conduct internal research activities and collaboration activities around delivery across our therapeutic platform. The successful candidate will report to the Associate Director, Delivery and will be an integral part of a cross functional team optimizing novel approaches for delivery for our gene therapy platform.


  • Develop strategy to optimize novel formulations based on understanding current critical technical and pharmacological barriers
  • Execute on an internal and external technical plan for the delivery group at Generation Bio.
  • Assist in developing and optimizing novel nanoparticle formulations for multiple delivery routes
  • Characterize nanoparticle formulations using various physicochemical and in vitro characterization techniques
  • Analyze data to enable optimization of formulation parameters/characteristics
  • Work closely with the chemistry, analytical, pharmacology and biology teams at Generation Bio to evaluate the formulations in cell-based and in vivo models
  • Help support external, technical interfaces for delivery: academic collaborations, industrial collaborations, and contract manufacturing organizations
  • Manage and mentor research associates


  • Ph.D. in Pharmaceutics, Materials Science, Polymer Chemistry, Chemical Engineering, Bioengineering, Chemistry, or related field
  • 3-8 years of industry experience preferred
  • Background in the area of nucleic acid formulation is desirable for this role. Specific background in lipid delivery vehicles preferred
  • Experience working with cross-functional teams including pharmacology, analytical, chemistry, drug discovery, etc
  • Experience characterizing formulations
  • Demonstrated ability to operate in a fast-paced environment
  • Ability to work in a highly collaborative, team-based environment a must
  • Demonstrate a sense of urgency, proactive thinking and multitasking are essential
  • Strong communication, interpersonal and organizational skills
  • Results-driven with excellent attention to details
  • Proven ability to effectively plan and organize complex work activities and prioritize task completion to meet schedules and deadlines

POSITION: Full-Time, Exempt

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Apply Now